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Know Everything About Histamine

Histamine is a natural compound found in the human body that regulates many important functions in daily life. Histamine's adaptability allows it to function as a conductor in the complex symphony of human physiology. To fully comprehend Histamine, it is necessary to understand the meaning and examples of physiological processes.

Physiological activities are the various processes and functions that occur within the human body at the cellular, tissue, organ, and systemic levels. These activities are essential for the survival and proper functioning of the body. An individual's well-being is heavily reliant on proper physiological activities, the absence of which results in a slew of health problems.

Key functionalities of Histamine

  • Histamine is a crucial neurotransmitter that maintains normal brain functions and the central nervous system.
  • Histamine plays a central role in digestion by signaling the release of gastric acid, which initiates protein breakdown for effective digestion.
  • Histamine also defends the immune system and protects against infections and trauma.
  • Histamine is essential for the human body's robust defense mechanisms and significantly reduces the occurrence of disease.

Understand Histamine Sensitivity

  • Excess of anything causes problems, including histamine. When there is an excess of histamine in the body, it can cause serious side effects.
  • Histamine reactions are most similar to those caused by food allergies; however, with advancements in the healthcare industry, it is now possible to understand the hidden causes as well.
  • Histamine sensitivity is detectable, and it differs from regular allergies that disrupt your daily routine.
  • Conditions such as "idiopathic" urticaria and angioedema (hives) demonstrate that histamine sensitivity is more than a symptom. It's a separate health issue that necessitates special attention and care.
Symptoms
Identifying Effects of Excessive Histamine
Vasodilatation
  • Flushing
  • Reddening
Hypotension
  • Tachycardia (increased heart rate)
Pruritus (itching)
  • Heartburn
  • Reflux
  • Night work/shift work
Increased Vascular permeability:
  • Urticaria (hives)
  • Angioedema (Swelling)
  • Rhinorrhoea (runny nose)
  • Otitis media (earache)

Histamine in Foods

FMD Histamine

Histamine is produced by microbial action in manufacture of foods such as:

  • Vinegar

  • Yeast extract

  • Sauerkraut

  • Cheese

  • Wine

  • Beers

  • Fermented meats and sausages

FMD Histamine

Histidine, a naturally occurring amino acids in foods, can be converted to Histamine by intestinal bacteria. Histidine may develop in fish that have been improperly processed or refrigerated, especially:

  • Tuna

  • Mackerel

  • Bonito

  • Bluefish

  • Mahi Mahi

  • Shelfish

FMD Histamine

Some foods naturally contain histamine, such as:

  • Spinach

  • Aubergine (eggplant)

FMD Histamine

Some foods develop histamine during the ripening process:

  • Tomatoes

  • Cherries

The role of diamine oxidase (DAO)

  • Diamine oxidase (DAO) is the first line of defense against histamine ingested from the diet or released in the gut.
  • When DAO levels are adequate and DAO activity is normal, only a small amount of extrinsic (outside) histamine enters the bloodstream.
  • Those who consume a histamine-rich diet and/or take medications that inhibit DAO activity are more sensitive to extrinsic histamine.
  • Histamine-restricted diets and DAO supplementation can be effective ways to manage histamine sensitivity.
  • Diamine oxidase (DAO) supplements should be taken 15 minutes before consuming histamine-rich foods.
  • Those who take medications that inhibit DAO activity may benefit from taking DAO supplements every day, regardless of diet.
  • While DAO supplements can be beneficial, dietary restrictions may also be required to effectively manage histamine sensitivity.